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Research behind our Products

Refer to this page for the list of successful clinical research studies that support the efficacy of our product formulations provided for each product.

Alpha Pure Products

Therapeutic plant-based solutions backed by proven research.

BIO3 collection

1.         Anzolin AP, da Silveira-Kaross NL, Bertol CD. Ozonated oil in wound healing: what has already been proven? Med Gas Res. 2020;10(1):54-59. doi:10.4103/2045-9912.279985

2.         Campanati A, De Blasio S, Giuliano A, et al. Topical ozonated oil versus hyaluronic gel for the treatment of partial- to full-thickness second-degree burns: A prospective, comparative, single-blind,  non-randomised, controlled clinical trial. Burns J Int Soc Burn Inj. 2013;39(6):1178-1183. doi:10.1016/j.burns.2013.03.002

3.         Currò M, Russo T, Ferlazzo N, et al. Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. Mol Basel Switz. 2018;23(3). doi:10.3390/molecules23030645

4.         Dharmavaram AT, Reddy RS, Nallakunta R. “Ozone” - the new NEMESIS of canker sore. J Clin Diagn Res JCDR. 2015;9(3):ZC01-04. doi:10.7860/JCDR/2015/11911.5617

5.         Gültekin FA, Bakkal BH, Sümer D, Köktürk F, Bektaş S. Effects of ozonated olive oil on acute radiation proctitis in rats. Balk Med J. 2013;30(4):369-374. doi:10.5152/balkanmedj.2013.9158

6.         Qin G, Huang J, Pan Y, et al. [Topical ozone application: An innovative therapy for infantile atopic dermatitis]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):163-167. doi:10.11817/j.issn.1672-7347.2018.02.010

7.         Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol. 2005;153(6):1096-1100. doi:10.1111/j.1365-2133.2005.06939.x

8.         Kim HS, Noh SU, Han YW, et al. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci. 2009;24(3):368-374. doi:10.3346/jkms.2009.24.3.368

9.         Qin G, Huang J, Pan Y, et al. [Topical ozone application: An innovative therapy for infantile atopic dermatitis]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):163-167. doi:10.11817/j.issn.1672-7347.2018.02.010

10.       Ugazio E, Tullio V, Binello A, Tagliapietra S, Dosio F. Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques. Mol Basel Switz. 2020;25(2). doi:10.3390/molecules25020334

11.       Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol. 2005;153(6):1096-1100. doi:10.1111/j.1365-2133.2005.06939.x

12.       Zanardi I, Burgassi S, Paccagnini E, Gentile M, Bocci V, Travagli V. What is the best strategy for enhancing the effects of topically applied ozonated oils in cutaneous infections? BioMed Res Int. 2013;2013:702949. doi:10.1155/2013/702949

13.       Zeng J, Lu J. Mechanisms of action involved in ozone-therapy in skin diseases. Int Immunopharmacol. 2018;56:235-241. doi:10.1016/j.intimp.2018.01.040

OLIVO3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435909/

https://www.eurekalert.org/pub_releases/2014-07/rb-ssf070814.php 
http://www.sciencedirect.com/science/article/pii/S0003986114002239 
https://dx.doi.org/10.1016/j.biopen.2017.09.001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100473/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751100/
https://doi.org/10.1002/ptr.5166
http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/2583/1/BOUZID%20DJIHANE%202.pdf

https://www.eurekalert.org/pub_releases/2014-07/rb-ssf070814.php 
http://www.sciencedirect.com/science/article/pii/S0003986114002239 
https://dx.doi.org/10.1016/j.biopen.2017.09.001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100473/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751100/
https://doi.org/10.1002/ptr.5166
http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/2583/1/BOUZID%20DJIHANE%202.pdf

https://www.tandfonline.com/doi/abs/10.1080/10826076.2019.1591977 
https://aac.asm.org/content/53/5/2209 
https://www.researchgate.net/publication/258635310_Helichrysum_italicum_From_traditional_use_to_scientific_data
http://www.ijnpnd.com/article.asp?issn=22310738;year=2012;volume=2;issue=2;spage=79;epage=79;aulast=Khan
https://www.ncbi.nlm.nih.gov/pubmed/24137478
https://www.ncbi.nlm.nih.gov/pubmed/27117114
https://www.ncbi.nlm.nih.gov/pubmed/19296830
https://www.ncbi.nlm.nih.gov/pubmed/11677605
https://www.ncbi.nlm.nih.gov/pubmed/26427766
https://www.ncbi.nlm.nih.gov/pubmed/29450150
https://www.ncbi.nlm.nih.gov/pubmed/15890469

OZOCLEAR

https://onlinelibrary.wiley.com/doi/10.1111/j.1439-0507.2010.01898.x

https://pubmed.ncbi.nlm.nih.gov/11168731/

https://www.eurekalert.org/pub_releases/2014-07/rb-ssf070814.php 
http://www.sciencedirect.com/science/article/pii/S0003986114002239 
https://dx.doi.org/10.1016/j.biopen.2017.09.001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100473/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751100/
https://doi.org/10.1002/ptr.5166
http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/2583/1/BOUZID%20DJIHANE%202.pdf

https://www.eurekalert.org/pub_releases/2014-07/rb-ssf070814.php 
http://www.sciencedirect.com/science/article/pii/S0003986114002239 
https://dx.doi.org/10.1016/j.biopen.2017.09.001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100473/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751100/
https://doi.org/10.1002/ptr.5166
http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/2583/1/BOUZID%20DJIHANE%202.pdf

https://www.tandfonline.com/doi/abs/10.1080/10826076.2019.1591977 
https://aac.asm.org/content/53/5/2209 
https://www.researchgate.net/publication/258635310_Helichrysum_italicum_From_traditional_use_to_scientific_data
http://www.ijnpnd.com/article.asp?issn=22310738;year=2012;volume=2;issue=2;spage=79;epage=79;aulast=Khan
https://www.ncbi.nlm.nih.gov/pubmed/24137478
https://www.ncbi.nlm.nih.gov/pubmed/27117114
https://www.ncbi.nlm.nih.gov/pubmed/19296830
https://www.ncbi.nlm.nih.gov/pubmed/11677605
https://www.ncbi.nlm.nih.gov/pubmed/26427766
https://www.ncbi.nlm.nih.gov/pubmed/29450150
https://www.ncbi.nlm.nih.gov/pubmed/15890469

VEGANO3

https://www.eurekalert.org/pub_releases/2014-07/rb-ssf070814.php 
http://www.sciencedirect.com/science/article/pii/S0003986114002239 
https://dx.doi.org/10.1016/j.biopen.2017.09.001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100473/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751100/
https://doi.org/10.1002/ptr.5166
http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/2583/1/BOUZID%20DJIHANE%202.pdf

https://www.eurekalert.org/pub_releases/2014-07/rb-ssf070814.php 
http://www.sciencedirect.com/science/article/pii/S0003986114002239 
https://dx.doi.org/10.1016/j.biopen.2017.09.001
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100473/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751100/
https://doi.org/10.1002/ptr.5166
http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/2583/1/BOUZID%20DJIHANE%202.pdf

https://www.tandfonline.com/doi/abs/10.1080/10826076.2019.1591977 
https://aac.asm.org/content/53/5/2209 
https://www.researchgate.net/publication/258635310_Helichrysum_italicum_From_traditional_use_to_scientific_data
http://www.ijnpnd.com/article.asp?issn=22310738;year=2012;volume=2;issue=2;spage=79;epage=79;aulast=Khan
https://www.ncbi.nlm.nih.gov/pubmed/24137478
https://www.ncbi.nlm.nih.gov/pubmed/27117114
https://www.ncbi.nlm.nih.gov/pubmed/19296830
https://www.ncbi.nlm.nih.gov/pubmed/11677605
https://www.ncbi.nlm.nih.gov/pubmed/26427766
https://www.ncbi.nlm.nih.gov/pubmed/29450150
https://www.ncbi.nlm.nih.gov/pubmed/15890469

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